Kaverina NV, Chichkanov GG, Tsorin IB, Kirsanova GIu
[Effect of the sympathetic nervous system activation on the antifibrillatory efficacy of various anti-arrhythmia agents] [Journal Article]
Eksp Klin Farmakol 2000 Nov-Dec; 63(6):22-3.
Experiments with a 7-min occlusion followed by reperfusion of the left coronary artery in narcotized rats showed that antiarrhythmic drugs of various classes--ethacizin (class I), AL-275 (class III), and CM-345 (class V)--produce pronounced antifibrillatory and antiarrhythmic effects. AL-275 and CM-345, in contrast to ethacizin, retained their efficacy under the conditions of isoproterenol-induced stimulation of beta-adrenoceptors. This difference in behavior is probably explained by dissimilar effects of the antiarrhythmics on the ion channels of cardiomyocite membranes.
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